While the show's freshman run followed therapist and newly divorced dad Drew Dunbar as he discovers he needs a new kidney, and later undergoes a successful transplant after Gina, a rough-around-the-edges woman from his past, volunteers to let him have one of her kidneys, the series underwent a creative revamp heading into Season 2. Pennette's exit marked just the latest change for the series, which returned to CBS with its Season 2 premiere on Thursday, Oct. At this time, neither Pennette nor CBS have addressed his departure, and it remains unclear why he is not attached to Season 2. According to the outlet, Pennette left his position after Season 1, which debuted on the network in November 2020 and concluded its freshman run in May of this year. Pennette executive produced B Positive - the series stars Thomas Middleditch, Annaleigh Ashford, Linda Lavin, and Anthony Higgins - with Chuck Lorre (The Big Bang Theory, Two-and-a-Half Men) and former Two and a Half Men executive producer/co-showrunner Jim Patterson. Deadline confirmed Pennette's exit from the series following the Season 2 premiere.
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